Dr. Miller will review progress over the past 5 years in building multi-scale models  that integrate the imaging millimeter scales of MRI with the mesoscales of digital  pathology and the sub-micron scales of spatial transcriptomics. He will describe new  particle methods that are universal for spatially clusters multi-scale measurements  to atlas partitions, also applications to understanding the spread of Alzheimer’s  disease throughout the macro and microscopic anatomy of the medial temporal lobe  will be reviewed. 

Bio: Michael I. Miller, Ph.D., Bessie Darling Massey Professor and Director of Biomedical Engineering at Johns Hopkins University. Dr. Miller is also co-director of the Kavli  Neuroscience Discovery Institute. As a biomedical engineer who specializes in  biomedical data science, Dr. Miller is pioneering cutting-edge technologies in  computational medicine to understand and diagnose neurodegenerative diseases. His  research focuses on the functional and structural characteristics of the human brain  in health and disease, focusing on neurodegenerative diseases Alzheimer’s and  Huntington’s. Dr. Miller has written two books, one entitled Random Point Processes  in Space and Time with Donald L. Snyder, and one entitled Pattern Theory: An  Emerging Discipline with Ulf Grenander. Dr. Miller has founded several companies in  biomedical technologies for brain mapping.