MSE Ph.D. Thesis Defense: “Stuck in the Matrix: How Chromatin Records and Replays Mechanical History”
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Glandt Forum, Singh Center for Nanotechnology
3205 Walnut Street, Philadelphia, PA, United States
Abstract: Tissues stiffen in aging, fibrosis, cancer, and injury, yet how these physical changes are recorded inside the nucleus has remained poorly understood. This dissertation establishes that matrix stiffness is not merely sensed at the cell surface and relayed biochemically inward. It is encoded directly in chromatin architecture, accumulated over time, and expressed as distinct […]

